Ibhalansi yamaxabiso e-pH kumzimba womntu

En Ok pool Reform, kweli candelo ngaphakathi kwe Amadama okuqubha akwinqanaba le-pH siya kuyiphatha i Ibhalansi yamaxabiso e-pH kumzimba womntu.

Ibhalansi yamaxabiso e-pH kumzimba womntu

Ixabiso le-pH lithetha ntoni kumzimba womntu?

I-pH sisikali esiyilelwe ukulinganisa i-alkalinity okanye ubumuncu bezinto, kwaye ibonisa ipesenti ye-hydrogen equlethwe kuyo.

Kufuneka kuqatshelwe ukuba iiseli zomzimba zidinga i-alkaline pH kancinane (phakathi kwe-7 kunye ne-7,4) ukuze isebenze ngokufanelekileyo. Ewe, usokhemisti uLinus Pauling, ophumelele amabhaso amabini eNobel, wangqina ukuba ukugcina umzimba kwi-alkaline pH yeyona nto iphambili ukonwabela impilo entle.

Iingqwalasela zebhayoloji zexabiso le-pH

Ukuqwalaselwa kwezinto eziphilayo kwixabiso le-pH: Iifom ze-Tautomeric ze-purines kunye ne-pyrimidines

• I-Tautomerization luhlobo olukhethekileyo lwe-isomerism apho iproton ifuduka kwicala elinye kwaye i-covalent bond ihamba kwelinye icala ngaphakathi kwe-molecule.
• Iziseko zePurine kunye nepyrimidine zikhona kwiifom ezahlukeneyo ze-tautomerized ngokuxhomekeke kwi-pH.
• Zichanekile, zenziwe zazenzekela kumzimba pH omalunga ne-7,4, kwaye ziyimfuneko kwi-hydrogen bonding ye-complementary base pairs kwi-DNA double helices kunye ne-RNA strands. Ke, i-pH igcina iimilo zendalo ezinokwakheka kukathathu kweealekyuli ze-nucleic acid.

Umdla webhayoloji wexabiso le-pH ye-isoelectric

• I-PH ichaphazela i-ionization yamaqela e-polar e-ionzable ye-amino acids, iiprotheni, i-nucleic acids, i-phospholipids, kunye ne-mucopolysaccharides.
• Kwi-pH ethile, ebizwa ngokuba yi-isoelectric pH yemolekyuli, imolekyuli nganye ikhona njenge-dipole zwitterions equlethe amaqela e-cationic kunye ne-anionic acid kunye nentlawulo encinci ye-net.
• Iiion zeZwitter azifuduki kumhlaba wombane kwaye zihamba ngokukhawuleza ngokudityaniswa ngenxa yokunganyangeki kwe-electrostatic.

Imisebenzi ehambelana namanqanaba e-pH emzimbeni

• Okokuqala, iinkqubo zokudambisa: Iiprotheyini ziyinxalenye yenkqubo ye-buffer yokulawula amanqanaba e-pH.
• Ulawulo lokuphefumla: I-pH yegazi phantsi kweemeko eziqhelekileyo yi-7,4. Nangona kunjalo, i-CO2 iyahlukana ibe yi-carbonic acid kwiithishu. Ngoko ke, ubukho be-CO2 eninzi benza igazi libe ne-asidi ngakumbi. Yiyo loo nto xa sibambe umphefumlo wethu ixesha elide, amanqanaba e-CO2 akhuphuka egazini, ehlisa i-pH yethu kwaye abangele ukuba siphume. Ngakolunye uhlangothi, ngexesha le-alkalosis okanye ukunyuka kwe-pH, ukuphefumla kunokunciphisa ukunyusa amanqanaba e-CO2 kunye nokunciphisa i-alkalinity. Nangona kunjalo, izinga eliphantsi lokuphefumla linokukhokelela kumanqanaba asezantsi eoksijini anokuba yingozi. Ngoko ke, ukuphefumla kunika ulawulo olubalulekileyo lokulawula amanqanaba e-pH.
• Inkqubo yezintso ilawula i-pH ye-extracellular fluid.
• Kwelinye icala kwakhona ibonelela ngokhuseleko kusulelo lwebhaktiriya. Kwi-pH eneasidi ezona meko zifanelekileyo zinikwa ukuphila kwezityalo zengingqi eziqhelekileyo. Iintsholongwane eziyibumbayo zenza eyona nkqubo yokhuselo ibalulekileyo ngokuchasene neearhente ze-pathogenic zemvelaphi yangaphandle.
• Kwaye ekugqibeleni, i-pH isebenza njenge umkhuseli kwizisombululo ze-alkaline ngokuchasene nosulelo lwesikhumba, ekubeni i-mantle ye-asidi ekhuselayo yolusu inoxanduva lokuyigcina ikhuselekile kwiimpembelelo zokusingqongileyo ezinokuyonakalisa. Ikhusela ulusu ngokuthe ngqo kwimiphumo yezisombululo ze-alkaline (umzekelo, xa uhlamba ngeesepha ze-alkaline, i-bleach ...). Ngokungathanga ngqo, ikhusela ikholoni ngebhaktheriya okanye umngundo kwaye ikhusela usulelo.

Ixabiso elifanelekileyo le-pH kumzimba womntu

Ixabiso elifanelekileyo le-pH kumzimba womntu

I-pH efanelekileyo yomzimba womntu yi-7 nangona iqhelekile ngeenxa zonke: 7.35-7.45.

Amaxabiso e-pH olwelo oluhlukeneyo lomzimba

Igazi le-Physiological pH liphakathi kwe-7.35 kunye ne-7.45 enexabiso eliphakathi kwe-7.4.

Ugqirha uhlola ibhalansi ye-asidi-base yomntu ngokulinganisa i-pH kunye namanqanaba ekharbon diokside (i-asidi) kunye ne-bicarbonate (isiseko) egazini.

I-pH engaphantsi kwe-7.35 yi-acidosis kwaye i-pH ephezulu kune-7.45 ibizwa ngokuba yi-alkalosis.

• Ukuze ugweme ukungalingani phakathi kwe-acids kunye neziseko ngexesha le-metabolism yemihla ngemihla, umzimba uneenkqubo ezininzi zokulawula. 
• Ke, ukuba ufuna ulwazi malunga nefuthe le-pH kwimpilo yethu yegazi, ungacofa eli khonkco lilandelayo: Ulungelelwaniso lweeasidi kunye neziseko kulwelo lomzimba womzimba wethu lubaluleke kakhulu.

Nangona i-pH yegazi ivela kwi-7,35 ukuya kwi-7,45, i-pH yolunye ulwelo lomzimba yahlukile.

• Ngokuphathelele i-pH yolwelo lomzimba, iyahluka kancinci phakathi kolwelo lwamacandelo ahlukeneyo omzimba.
• Ukuya kuthi ga kwinqanaba legazi le-arterial, i-pH yi-7,4, kwigazi le-venous kunye ne-interstitial fluid yi-7,35, ngelixa i-pH yeselula ephakathi yi-7,0.
• Okwangoku, kwi-physiology yokuphefumula sibona ukuba igazi le-venous liqulethe i-CO eninzi₂ kunegazi le-arterial kunye nokuba kukho ulungelelwaniso oluthe ngqo phakathi kwe-CO₂ kunye pH, ukuze CO ngakumbi₂, i-pH ephantsi. Oku kuchaza umahluko kwi-pH phakathi kwegazi le-venous kunye ne-arterial.

Kwisisu, i-pH iphakathi kwe-1,5 - 3. Amaxesha angama-100.000 ngaphezu kwe-acidic kunegazi.

Ixabiso elifanelekileyo le-pH esiswini

I-pH ibonisa inqanaba le-H+ ion, kunye ne-pH ephantsi ebonisa i-H+ ion ezininzi kunye ne-pH ephezulu ebonisa i-OH- ion ezininzi kakhulu. Ukuba amanqanaba e-pH ehla ngaphantsi kwe-6,9, oko kunokukhokelela kwi-coma. Nangona kunjalo, ulwelo oluhlukeneyo lomzimba lunamaxabiso ahlukeneyo e-pH.

• I-pH yamathe iphakathi kwe-6,5 kunye ne-7,5. Emva kokugwinya, ukutya kufikelela kwisisu apho iindawo eziphezulu kunye nezisezantsi zesisu zinemilinganiselo ye-pH eyahlukileyo.
• Indawo engasentla ine pH ye 4 ukuya ku 6,5, logama indawo esezantsi ine asidi kakhulu ne pH ye 1,5 ukuya ku 4,0.
• Emva koko ingena emathunjini ane-alkaline kancinane, ene-pH ye-7-8.5. Ukugcina amaxabiso e-pH kwimimandla eyahlukeneyo kubalulekile kumsebenzi wabo.

pH yamanzi okusela

pH kunye namanzi amatsha

• Umzimba womntu ubunjwe ngamanzi angama-70 ekhulwini. Ngoko ayimangalisi into yokuba i-H2O idlala indima ebalulekileyo ekuzinziseni inqanaba le-pH lendalo. Eso sesinye sezizathu zokuba sisoloko sixelelwa ukuba sisele amanzi amaninzi. Kodwa hayi nje nawaphi na amanzi. Amanzi ane-pH ephakathi kwe-7,2 kunye ne-7,8 afanelekile ukugcina impilo entle.
• Xa sisela ulwelo oluneasidi kakhulu okanye ezinealkaline kakhulu, lunokubangela ukuba umzimba ulungelelane, nto leyo enokukhokelela ekukhuleni kweentsholongwane, iintsholongwane, ukungunda, igwele nezifunxi-gazi. Okukwintsusa? Wakhethe ngobulumko amanzi akho kwaye uwasele kakhulu.

Ixabiso le-pH yamanzi okusela: 6.5 ukuya kwi-8.5

• El pH eyamkelekileyo ngenxa amanzi okusela yahluka phakathi kwe-6.5 ukuya kwi-8.5 njengexabiso lesikhokelo (^{Jimenez, 2001}). Ngoku ka ^{Galvin (2003}), ukwenzela i amanzi Ukusetyenziswa komntu, amaxabiso agqithisileyo anokubangela ukucaphuka kwi-mucous membranes, ukucaphuka kwizitho zangaphakathi kunye neenkqubo zesilonda.

I-pH amanzi adityanisiwe

ph ixabiso lamanzi adibeneyo

• Amanzi acocekileyo, ngokwenkcazo, aneasidi kancinane kwaye amanzi adityanisiweyo aya kuba ne-pH emalunga ne-5,8. Isizathu kukuba amanzi adiyiweyo anyibilikisa ikharbon diokside esuka emoyeni.
• Inyibilikisa ikharbon diokside de ibe kwi-dynamic equilibrium kunye neatmosfera. 4.5-5.0 Ubuninzi bokucoceka kwezo zixhobo zikholisa ukuba yi-1.0 MWcm; kwaye ekubeni akukho khuseleko kwi-carbon dioxide (CO2) echithwa kwi-distillate, i-pH ngokubanzi yi-4.5-5.0.

I-Balance repercussion ixabiso le-pH

Ibhalansi ye-acid-base yezinga le-pH emzimbeni

Ukulawulwa kwe-acid-base balance, oko kukuthi, i-pH, ibalulekile kumzimba.

Ii-Enzymes kunye neenkqubo ze-biochemical zisebenza ngokugqibeleleyo kuphela kuluhlu oluthile lwe-pH, ngaloo ndlela zitshabalalisa ezinye ii-enzymes ukuba inqanaba le-asidi-base kulwelo lomzimba aliqhelekanga.

i-alkaline yomzimba womntu pH

Ukubaluleka kokulinganisela kwe-pH: Ukugcina i-pH ngaphezu kwe-7 okanye i-alkaline iyona siqinisekiso sempilo.

ph impilo amaxabiso aqhelekileyo

• Imizimba yethu iphila kwaye ife kwinqanaba leselula kwaye iiseli kufuneka zigcine i-alkalinity ukuze zisebenze kwaye zihlale ziphila. Isimo se-acidic sibangela ukunqongophala kweoksijini kwinqanaba leselula.

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Ukubaluleka kwe-pH kwimpilo

amaphiko ph kunye nempilo

Emva koko, inkcazo emfutshane yengcamango ye-hydrogen enokubakho kunye nokubaluleka kwayo kwimpilo.

Iziphazamiso zokungalingani ph impilo amaxabiso aqhelekileyo

Ulungelelwaniso lweeasidi kunye neziseko kulwelo lomzimba womzimba wethu lubaluleke kakhulu.

• Ukungalingani kunokubangela acidosis (i-acidity egqithisileyo) okanye ialkalosis (isiseko esigqithisileyo) emzimbeni wethu, ukuphazamiseka kwemetabolism, ebonakaliswa yimpawu ezinokuthi ngaphandle konyango zibe neziphumo ezibi.
• Ngaphezu koko, ukubunjwa kunye nokukhula kwe-pathogens ekudleni kufuna izondlo, amanzi, ukushisa okwaneleyo kunye namanqanaba athile e-pH. Amaxabiso e-pH ekutyeni aqala kwi-1 ukuya kwi-14, kwaye i-7 ithathwa njengexabiso elingathathi hlangothi. Ukuba inqanaba le-pH ekutyeni lingaphezulu kwe-7, kuthiwa i-alkaline; ngakolunye uhlangothi, ixabiso elingaphantsi kwe-7 libonisa ukutya okumuncu.

I-pH engaphantsi kwe-7,4 ayilunganga kwaye ibonelela ngemekobume egqibeleleyo yebhaktheriya, ukungunda kunye nokukhula kwentsholongwane.

I-Acidosis: Iimpembelelo ze-pH ezingaphantsi kwe-7,4 kumzimba womntu

I-Acidosis yimeko ebangelwa kukuveliswa ngokugqithiseleyo kweasidi ethi ikhule egazini okanye ngenxa yokulahlekelwa ngokugqithisileyo kwebicarbonate (metabolic acidosis). Ngokufanayo, inokubangelwa kukugcwala kwekharbon diokside ephuma kukungasebenzi kakuhle kwemiphunga (i-acidosis yokuphefumla).

• I-pH ephantsi okanye ene-acidic nayo ibangela ukuba umzimba ugcine i-asidi kwiiseli zethu ezinamafutha, okubangela ukuveliswa kweeseli ezinamafutha amaninzi (into yokugqibela esiyidingayo!). ngokubuyisela umzimba wakho kumgangatho we-pH ochanekileyo, sivumela umzimba wethu ukuba uphulukane neeseli zamafutha ezingafunwayo.
• Ukuxinezeleka, ukungabikho kokuzivocavoca kunye nokutya okungahambi kakuhle kunciphisa i-pH yegazi kwaye kunokukhokelela kwizifo.
• Ukutya okune-Acidic kuthathwa njenge-pH engaphantsi kwe-4,6 kwaye kufuneka kugwenywe, kubandakanywa neziselo ezithambileyo, ukutya okucutshungulwayo, intlanzi, iswekile, iinkozo kunye nenyama esetyenzisiweyo.
• Ngapha koko, i-pH ephantsi okanye ene-asidi yenye yezona zizathu zibalulekileyo zezifo ezininzi, ezinjengomhlaza, umzekelo, kuba kufunyaniswe ukuba i-85% yezigulana ezinomhlaza zinamanqanaba e-pH phakathi kwe-5 kunye ne-6.

Alkalosis: Ukungalingani ph impilo amaxabiso aqhelekileyo

• IAlkalosis yimeko equka ialkalinity egqithisileyo egazini ebangelwa kubuninzi bebicarbonate okanye ukulahleka kweasidi (metabolic alkalosis). Isenokubangelwa kukwehla kwekharbon diokside egazini okubangelwa kukuphefumla ngokukhawuleza okanye ngokunzulu (i-respiratory alkalosis). Nangona ingaphantsi kwe-acidosis, i-alkalosis ikwabangela ukungalingani kwe-pH.

Iziphazamiso kwibhalansi ye-pH yexabiso lempilo

Ukungalingani ph amaxabiso aqhelekileyo impilo

Ukungalingani kwe-pH yexabiso lempilo: ukuphazamiseka kwe-asidi-base balance. i-metabolic kunye ne-alkalosis yokuphefumula.