En Ok Pauv Reform, nyob rau hauv nqe lus no nyob rau hauv lub pH theem pas ua luam dej peb yuav kho cov Qhov sib npaug ntawm pH qhov tseem ceeb hauv tib neeg lub cev.
Qhov sib npaug ntawm pH qhov tseem ceeb hauv tib neeg lub cev
Tus nqi pH txhais li cas rau tib neeg lub cev?
Lub pH yog ib qho ntsuas tsim los ntsuas qhov alkalinity lossis acidity ntawm cov khoom, thiab qhia txog qhov feem pua ntawm hydrogen muaj nyob hauv nws.
Nws yuav tsum tau muab sau tseg tias lub hlwb ntawm lub cev xav tau ib tug me ntsis alkaline pH (nruab nrab ntawm 7 thiab 7,4) ua hauj lwm kom zoo. Tseeb tiag, tus kws kho mob Linus Pauling, tus yeej ntawm ob qhov khoom plig Nobel, tau lees paub tias ua kom lub cev ntawm alkaline pH yog qhov tseem ceeb rau kev noj qab haus huv.
Biological kev txiav txim siab ntawm tus nqi pH
Biological kev txiav txim siab ntawm tus nqi pH: Tautomeric cov ntaub ntawv ntawm purines thiab pyrimidines
- Tautomerization yog ib hom tshwj xeeb ntawm isomerism qhov twg proton migrates nyob rau hauv ib qho kev taw qhia thiab covalent daim ntawv cog lus txav mus rau qhov opposite kev taw qhia nyob rau hauv lub molecule.
- Purine thiab pyrimidine bases muaj nyob rau hauv cov ntaub ntawv tautomerized sib txawv nyob ntawm pH.
- Lawv yog cov tshwj xeeb, tautomerized ntawm lub cev pH ntawm txog 7,4, thiab yog qhov tseem ceeb rau hydrogen bonding ntawm complementary puag khub hauv DNA ob helices thiab RNA strands. Yog li, pH tswj cov duab peb-dimensional ntawm nucleic acid molecules.
Biological txaus siab ntawm isoelectric pH tus nqi
- PH cuam tshuam rau ionization ntawm ionizable polar pawg ntawm cov amino acids, proteins, nucleic acids, phospholipids, thiab mucopolysaccharides.
- Ntawm ib qho pH tshwj xeeb, hu ua isoelectric pH ntawm cov molecule, txhua lub molecule tshwm sim raws li dipolar zwitterions uas muaj cationic thiab anionic acid pawg thiab tsawg kawg nkaus xwb.
- Zwitter ions tsis tsiv mus nyob rau hauv hluav taws xob teb thiab yooj yim precipitate los ntawm aggregation vim tsawg heev electrostatic repulsion.
Kev ua haujlwm cuam tshuam nrog qib pH hauv lub cev
- Ua ntej ntawm tag nrho cov, damping systems: Proteins yog ib feem ntawm lub cev tsis muaj zog los tswj cov qib pH.
- Kev tswj ua pa: pH ntawm cov ntshav nyob rau hauv ib txwm muaj yog 7,4. Txawm li cas los xij, CO2 dissociates rau carbonic acid hauv cov ntaub so ntswg. Yog li ntawd, muaj ntau CO2 ua rau cov ntshav acidic ntau dua. Tias yog vim li cas thaum peb tuav peb ua tsis taus pa ntev, CO2 qib nce hauv cov ntshav, txo peb cov pH thiab ua rau peb dhau mus. Ntawm qhov tod tes, thaum lub sij hawm alkalosis los yog nce pH, ua pa tuaj yeem qeeb kom nce CO2 qib thiab txo alkalinity. Txawm li cas los xij, qhov ua pa qis kuj tuaj yeem ua rau cov pa oxygen tsawg uas yuav ua rau muaj kev phom sij. Yog li ntawd, kev ua pa muaj kev tswj xyuas tseem ceeb los tswj cov qib pH.
- Lub raum system tswj cov pH ntawm cov kua dej extracellular.
- Ntawm qhov tod tes thiab muab kev tiv thaiv tiv thaiv kab mob. Ntawm acidic pH qhov zoo tshaj plaws tej yam kev mob yog muab rau cov ciaj sia taus ntawm lub regional flora. Cov kab mob uas tsim nws yog qhov tseem ceeb tshaj plaws tiv thaiv kab mob tiv thaiv kab mob ntawm cov neeg tuaj txawv teb chaws.
- Thiab thaum kawg, pH ua haujlwm li tiv thaiv alkaline daws cov kab mob ntawm daim tawv nqaij, txij li cov tshuaj tiv thaiv acid mantle ntawm daim tawv nqaij yog lub luag haujlwm ua kom nws tiv thaiv los ntawm ib puag ncig cuam tshuam uas tuaj yeem ua rau nws puas tsuaj. Nws tiv thaiv daim tawv nqaij ncaj qha rau cov teebmeem ntawm alkaline daws (piv txwv li, thaum ntxuav nrog alkaline soaps, tshuaj dawb ...). Indirectly, nws tiv thaiv colonization los ntawm cov kab mob los yog fungi thiab tiv thaiv kab mob.
Qhov zoo tshaj pH tus nqi rau tib neeg lub cev
Qhov zoo tshaj pH tus nqi hauv tib neeg lub cev
Qhov zoo tshaj pH ntawm tib neeg lub cev yog 7 txawm tias nws ib txwm nyob ib puag ncig: 7.35-7.45.
pH qhov tseem ceeb ntawm cov kua dej sib txawv ntawm lub cev
Physiological ntshav pH nyob nruab nrab ntawm 7.35 thiab 7.45 nrog tus nqi nruab nrab ntawm 7.4.
Tus kws kho mob soj ntsuam ib tus neeg cov kua qaub-puag los ntawm kev ntsuas pH thiab qib carbon dioxide (ib qho kua qaub) thiab bicarbonate (lub hauv paus) hauv cov ntshav.
pH qis dua 7.35 yog acidosis thiab pH siab dua 7.45 hu ua alkalosis.
- Txhawm rau tiv thaiv qhov tsis sib xws ntawm cov kua qaub thiab cov hauv paus hauv cov metabolism hauv txhua hnub, lub cev muaj ntau yam kev tswj hwm.
- Yog li, yog tias koj xav tau cov ntaub ntawv hais txog cov txiaj ntsig ntawm pH ntawm peb cov ntshav kev noj qab haus huv, koj tuaj yeem nyem rau ntawm qhov txuas hauv qab no: Qhov sib npaug ntawm cov kua qaub thiab cov hauv paus hauv cov kua dej ntawm peb lub cev yog qhov tseem ceeb heev.
Txawm hais tias pH ntawm cov ntshav nyob ntawm 7,35 txog 7,45, pH ntawm lwm cov kua hauv lub cev txawv.
- Raws li rau pH ntawm cov kua hauv lub cev, nws txawv me ntsis ntawm cov kua dej ntawm qhov sib txawv ntawm lub cev.
- Raws li qhov uas nyob rau hauv cov ntshav arterial, pH yog 7,4, nyob rau hauv cov ntshav venous thiab interstitial kua nws yog 7,35, thaum lub sij hawm lub cellular pH yog 7,0.
- Lub sijhawm no, hauv kev ua pa ntawm lub cev peb pom tias cov ntshav venous muaj CO ntau dua2 tshaj cov ntshav arterial thiab tias muaj kev sib raug zoo ntawm CO2 thiab pH, kom ntau CO2, qis pH. Qhov no piav qhia qhov sib txawv ntawm pH ntawm venous thiab arterial ntshav.
Hauv plab, pH nyob nruab nrab ntawm 1,5 - 3. 100.000 npaug ntau acidic dua hauv cov ntshav.
Qhov zoo tshaj pH tus nqi hauv plab
pH qhia txog qib H + ions, nrog pH qis qhia H + ions ntau dhau thiab siab pH qhia ntau dhau OH- ions. Yog tias pH qib qis qis dua 6,9, nws tuaj yeem ua rau coma. Txawm li cas los xij, cov kua dej sib txawv hauv lub cev muaj qhov sib txawv pH.
- Cov kua qaub pH nyob nruab nrab ntawm 6,5 thiab 7,5. Tom qab nqos, cov zaub mov mus txog lub plab qhov chaw ntawm lub plab thiab sab sauv muaj pH sib txawv.
- Sab sauv muaj pH ntawm 4 mus rau 6,5, thaum lub qis yog acidic heev nrog pH ntawm 1,5 txog 4,0.
- Tom qab ntawd nws nkag mus rau hauv cov hnyuv uas yog me ntsis alkaline, nrog pH ntawm 7-8.5. Kev tswj hwm tus nqi pH ntawm cov cheeb tsam sib txawv yog qhov tseem ceeb rau lawv txoj haujlwm.
pH ntawm cov dej haus
pH thiab dej tshiab
- Tib neeg lub cev yog tsim los ntawm 70 feem pua dej. Yog li nws tsis yog qhov xav tsis thoob tias H2O ua lub luag haujlwm tseem ceeb hauv kev ruaj khov ntawm peb lub ntuj pH. Qhov ntawd yog ib qho laj thawj vim li cas peb ib txwm hais kom haus dej ntau. Tab sis tsis yog dej xwb. Dej nrog pH ntawm 7,2 thiab 7,8 yog qhov zoo tagnrho rau kev noj qab haus huv.
- Thaum peb haus cov kua dej uas acidic lossis alkaline dhau lawm, lawv tuaj yeem ua rau lub cev tsis txaus siab, uas tuaj yeem ua rau muaj kab mob, kab mob, fungi, poov xab, thiab kab mob cab. Hauv qab kab? Xaiv koj cov dej kom zoo thiab haus dej kom ntau.
pH tus nqi ntawm cov dej haus: 6.5 txog 8.5
- El pH txaus rau haus dej Nws txawv ntawm 6.5 txog 8.5 raws li tus nqi qhia (Jimenez, 2001). Raws li Galvin (2003), rau cov dej ntawm tib neeg noj, qhov tseem ceeb heev tuaj yeem ua rau khaus khaus hauv daim tawv nqaij, khaus khaus hauv cov kab mob hauv nruab nrog cev thiab txawm tias cov txheej txheem ulceration.
pH demineralized dej
ph nqi ntawm cov dej distilled
- Cov dej ntshiab, los ntawm kev txhais, yog me ntsis acidic thiab cov dej distilled yuav muaj pH ntawm ib ncig ntawm 5,8. Yog vim li cas yog cov dej distilled dissolves carbon dioxide los ntawm huab cua.
- Nws dissolves carbon dioxide kom txog thaum nws nyob rau hauv dynamic equilibrium nrog cov cua. 4.5-5.0 Qhov siab tshaj plaws purity ntawm xws li tseem yog feem ntau 1.0 MWcm; thiab vim tias tsis muaj kev tiv thaiv los ntawm carbon dioxide (CO2) yaj hauv distillate, pH feem ntau yog 4.5-5.0.
Ntsuas qhov cuam tshuam pH tus nqi
Kev sib npaug ntawm cov kua qaub-pH ntawm lub cev
Kev tswj hwm ntawm acid-base tshuav, uas yog, pH, yog qhov tseem ceeb rau lub cev.
Cov enzymes thiab cov txheej txheem biochemical ua haujlwm tau zoo tsuas yog nyob rau hauv ib qho pH ntau yam, yog li rhuav tshem qee cov enzymes yog tias cov kua qaub hauv lub cev tsis zoo.
alkaline tib neeg lub cev pH
Qhov tseem ceeb ntawm pH tshuav nyiaj li cas: Kev tuav lub pH siab tshaj 7 los yog alkaline yog qhov zoo tshaj plaws lav kev noj qab haus huv.
ph noj qab haus huv ib txwm muaj nqis
- Peb lub cev muaj sia nyob thiab tuag ntawm qib cellular thiab cov hlwb yuav tsum tswj hwm alkalinity thiaj li ua haujlwm thiab ua neej nyob. Lub xeev acidic ua rau tsis muaj oxygen ntawm cov cellular theem.
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Qhov tseem ceeb ntawm pH hauv kev noj qab haus huv
wingspan ph thiab noj qab haus huv
Tom qab ntawd, piav qhia luv luv ntawm lub tswvyim ntawm hydrogen peev xwm thiab nws qhov tseem ceeb rau kev noj qab haus huv.
Kev tsis sib haum xeeb ntawm ph noj qab haus huv ib txwm muaj nuj nqis
Qhov sib npaug ntawm cov kua qaub thiab cov hauv paus hauv cov kua dej ntawm peb lub cev yog qhov tseem ceeb heev.
- Kev tsis sib xws tuaj yeem ua rau tshuaj mob ntsws (ntau acidity) los yog alkalosis (qhov tseem ceeb tshaj) nyob rau hauv peb lub cev, cov kab mob metabolic, uas yog cov tsos mob uas tsis muaj kev kho mob tuaj yeem muaj qhov tshwm sim loj.
- Tsis tas li ntawd, kev tsim thiab kev loj hlob ntawm cov kab mob hauv cov zaub mov xav tau cov as-ham, dej, qhov kub txaus thiab qee qhov pH. Tus nqi pH hauv cov khoom noj muaj li ntawm 1 txog 14, thiab 7 yog suav tias yog tus nqi nruab nrab. Yog tias pH qib hauv cov zaub mov ntau dua 7, nws tau hais tias yog alkaline; Ntawm qhov tod tes, tus nqi qis dua 7 qhia tias cov khoom noj muaj kua qaub.
Qhov pH qis dua 7,4 yog qhov zoo tshaj plaws thiab muab qhov chaw zoo tshaj plaws rau cov kab mob, pwm thiab kab mob loj hlob.
Acidosis: cuam tshuam pH qhov tseem ceeb hauv qab 7,4 ntawm tib neeg lub cev
Acidosis yog ib yam mob uas tshwm sim los ntawm kev tsim cov kua qaub ntau dhau uas tsim nyob rau hauv cov ntshav lossis los ntawm kev poob ntawm bicarbonate ntau dhau (metabolic acidosis). Ib yam li ntawd, nws tuaj yeem tshwm sim los ntawm kev tsim cov pa roj carbon dioxide los ntawm lub ntsws ua haujlwm tsis zoo (ua pa acidosis).
- Ib qho pH qis lossis acidic kuj ua rau lub cev khaws cov kua qaub hauv peb cov roj ntsha, uas ua rau muaj cov roj ntsha ntau ntxiv (qhov kawg peb xav tau!). yog li… los ntawm kev xa koj lub cev rov qab mus rau qib pH kom raug, peb tso cai rau peb lub cev kom tsis txhob muaj cov rog uas tsis xav tau.
- Kev ntxhov siab, tsis muaj kev tawm dag zog thiab kev noj zaub mov tsis zoo txo qis pH ntawm cov ntshav thiab tuaj yeem ua rau muaj kab mob.
- Cov khoom noj uas muaj kua qaub raug suav hais tias muaj pH qis dua 4,6 thiab yuav tsum zam, suav nrog cov dej qab zib, cov zaub mov tiav, ntses, qab zib, nplej, thiab cov nqaij ua tiav.
- Qhov tseeb, pH qis lossis acidic yog ib qho tseem ceeb ntawm ntau yam kab mob, xws li mob qog noj ntshav, piv txwv li, vim nws tau pom tias 85% ntawm cov neeg mob qog noj ntshav muaj pH ntawm 5 thiab 6.
Alkalosis: Imbalances ph noj qab haus huv ib txwm muaj nuj nqis
- Alkalosis yog ib yam mob uas muaj ntau dhau alkalinity ntawm cov ntshav los ntawm bicarbonate abundance los yog acid poob (metabolic alkalosis). Nws kuj tuaj yeem tshwm sim los ntawm qib qis ntawm cov pa roj carbon dioxide hauv cov ntshav uas tshwm sim los ntawm kev ua pa nrawm lossis tob (ua pa alkalosis). Txawm hais tias tsawg dua li acidosis, alkalosis kuj ua rau pH tsis txaus.
Kev puas tsuaj ntawm qhov sib npaug ntawm pH tus nqi noj qab haus huv
Imbalance ph ib txwm muaj nuj nqis kev noj qab haus huv
Kev tsis txaus ntawm pH tus nqi noj qab haus huv: teeb meem ntawm acid-base tshuav nyiaj li cas. metabolic thiab ua pa alkalosis.